850 mg, 500 mg

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For Diabetes, Type 2

I have been using Metformin for 3 months to aggressively treat my pre-diabetic condition. Together with a lower-carb (185-200 mg per day/1700 calories) I have lost 29 pounds. This is about double the weight loss rate I had on the diet alone. The only side effect I have experienced is a loose stool once or twice a week. Definitely a good trade-off! I am a 49 year old female, moderately active who has had a hysterectomy.

General information

An overdose of metformin may cause lactic acidosis, which may be fatal.


Kombiglyze XR


  • Metformin works well with other medicines, giving rise to precious few drug interactions.

Other Doses

850 mg, 500 mg
500 mg
1000 mg
850 mg
750 mg
500 mg/5 mL


Drug interactions, side effects, dosage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
In children, the usual dose is 10mg to 20mg once a day.
Do not take more than one dose in one day and do not take a double dose to make up for a missed one.


Birth control pills also increase this risk, particularly as a woman gets older.
If overdose occurs, the patient should be monitored for at least 10 hours and standard supportive treatment applied as required.


  • These effects are consistent with the inhibition of estrogen synthesis in rats and may be a result of known effects of lowered estrogen on pregnancy, organogenesis, and parturition.
  • Tell your doctor immediately if you miss your menstrual period, since this medication must not be used if you are pregnant.
  • You will also need to be tested for pregnancy in a laboratory each month during your treatment.
  • Use birth control that you can trust to prevent pregnancy while taking this medicine.

Liver disease is a risk factor for lactic acidosis.

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NIH, research is inconclusive on all of these topics. Insulin, glucagon, glucose, lactate, and NEFAs were log transformed before the statistical analyses to favor normality of residuals and Metormin of variance. Insulin is a hormone made by an organ in the body called the pancreas.


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