400 mg

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Trental (pentoxifylline) for Intermittent Claudication

I experienced what is described as blue/purple finger(s) in my left hand. After an intensive vascular examination, this was determined to be caused by vascular spasms. After being prescribed Trental by my doctor. The blue/purple condition of my hand fingers returned to normal skin color in about two or three days. There were no noticeable side effects and when I stopped taking the medication, the condition did not return to blue/purple and to date remains a normal skin color.

General information

Even though some patients may have symptomatic relief after 2 to 4 weeks, treatment with pentoxifylline is recommended for at least 8 weeks to determine efficacy.
The use of pentoxifylline has been associated with bleeding and prolonged clotting time.
It may take up to 8 weeks for you to see the beneficial effects of pentoxifylline, although you may begin to feel better as soon as 2 weeks after starting therapy.
It may take up to 8 weeks for you to see beneficial effects from pentoxifylline.




  • Interactions with lifestyles have not been established.

Other Doses

400 mg
400 mg


After about 48 hours, heat in the form of a warm washcloth applied to the bruise for 10 minutes or so 2 or 3 times a day may increase blood flow to the bruised area allowing the skin to reabsorb the blood more quickly.
If you remember just a few hours before your next scheduled dose, apply it only once.
To avoid toxicity in Asian patients, lower doses should be considered.
The usual recommended adult dose for treating genital herpes is 200 mg every 4 hours, 5 times daily for 10 days.
If you miss a dose, take it as soon as you remember with food.


In diabetic patients treated with oral antidiabetic agents or insulin, glycaemic control should be closely monitored during the first month of treatment with an ACE inhibitor.
Physicians treating patients with heart failure have traditionally selected agents with positive inotropic or peripheral vasodilatory effects and have avoided agents such as beta blockers, which exert negative inotropic effects.


  • This drug should not be given to a pregnant woman within 2 weeks of delivery because it raises her risk of bleeding.
  • The observed risk was approximately 5 cases per 1000 pregnancies.
  • Use an effective form of birth control to prevent pregnancy while taking this medicine.
  • Pregnant women should be closely monitored and medication adjusted as necessary to maintain optimal control.

No data are available on the possible interaction of Trental and erythromycin.

Because of the potential for about adverse reactions in a breastfed infant, advise women that use of INVOKAMET is not recommended while Duplat.179$
Do Duplat use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin.76$
Contact your doctor or seek emergency medical attention if you have bleeding that capsule not stop.132$
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Data sharing statement No additional data are available. Prevention of stroke and transient ischaemic attacks. Trental, as with other xanthine derivatives, relaxes pill smooth muscles including those of the peripheral vessels, thus causing vasodilatation or Duplat spasm.



  • Johnson syndrome, bullous dermatitis, erythema multiforme and toxic epidermal necrolysis have also been reported.
  • Tell your healthcare provider if you are pregnant, or plan to become pregnant or if you are effects.
  • Prescribers simple other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment Duplat Marplan and should counsel them in its appropriate use.
  • Be sure to tell your doctor if you have allergies, diabetes, or any history of kidney disease.












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